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Efficacy of Calcipotriol Plus Betamethasone Dipropionate Topical Ointment on100Targeted Lesions of52Cases of Psoriasis Vulgaris: an Open-label, Non-Randomized, Clinical Observational Study

作　者: 舒皖（Shuva Kant Sharma Gautam）
导　师: 黄长征
学　校: 华中科技大学
专　业: 皮肤性病学
关键词: psoriasis vulgaris calcipotriol betamethasone dipropionate PASI
分类号: R758.63
类　型: 硕士论文
年　份: 2013年
下　载: 1次
引　用: 0次
阅　读: 论文下载

内容摘要

Background/Objectives: The objective of this clinical study was to evaluatethe efficacy of a combined topical ointment containing calcipotriol50μg/gplus betamethasone dipropionate0.5mg/g in the treatment of mild to moderatepsoriasis vulgaris on the trunk and limbs.Methods: This study was an open-label, non-randomized, clinicalobservational study. A combination topical ointment containing calcipotriolplus betamethasone dipropionate was applied once daily on100targetedlesions of psoriasis vulgaris, from the trunk, limbs in52subjects. Theeffectiveness of the combined topical ointment was evaluated by PsoriasisArea and Severity Index (PASI). The primary response criteria werepercentage reduction in PASI score from baseline to the end of (1to10) weeksof treatment.Results: The mean reduction in PASI from mean baseline PASI of9.6to theend of10weeks of treatment was56.35%, without any substantial drugadverse reactions notified. At week10, a statistically significantly (P<0.0001)was achieved in comparison with the PASI score at baseline.Conclusions: Once a day treatment with the combined topical ointmentcontaining calcipotriol50μg/g plus betamethasone diproprionate0.5mg/g is asafe and effective therapeutic regimen for psoriasis vulgaris on the body.

全文目录

ABSTRACT  5-6
INTRODUCTION  6-17
SUBJECTS AND METHODS  17-20
RESULTS  20-31
DISCUSSION  31-36
REFERENCES  36-40
RESEARCH ACTIVITIES  40-41
ACKNOWLEDGEMENTS  41-42

Efficacy of Calcipotriol Plus Betamethasone Dipropionate Topical Ointment on100Targeted Lesions of52Cases of Psoriasis Vulgaris: an Open-label, Non-Randomized, Clinical Observational Study

内容摘要

全文目录

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